2024
Madan A*, Kelly KP*, Sullivan CE, Poling ME, Brent AE, Alassaf M, Dubrulle J, Rajan A.
Atg8-LC3 controls systemic nutrient surplus signaling in flies and humans. bioRχiv (2023). Current Biology (2024). Highlighted as a Featured article with a Dispatches essay by Andrew Leidal.
Atg8/LC3’s bidirectional role in nutrient sensing—conveying nutrient surplus and responding to nutrient deprivation—enables organisms to manage nutrient flux effectively.
Alassaf M & Rajan A. Adipocyte metabolic state regulates glial phagocytic function. bioRxiv 2024. PMID:39386724.
Rajan A. Communication between organs defines their sex-specific shapes. Nature(2024).
2023
Alassaf M & Rajan A. Diet-induced glial insulin resistance impairs the clearance of neuronal debris. PLoS Bio (2023). https://doi.org/10.1371/journal.pbio.3002359
2022
Kelly KP*, Alassaf M*, Sullivan CE, Brent AE, Goldberg ZH, Poling ME, Dubrulle J, Rajan A. Fat Body Phospholipid State Dictates Hunger Driven Feeding Behavior. eLife (2022). *equal contribution. https://doi.org/10.7554/eLife.80282
2019/ 2020
Brent AE and Rajan A. (2019). Insulin and Leptin/Upd2 exert opposing control on fat-sensing neurons synapse number. bioRχiv (2019). Cell Metabolism (2020). doi: 10.1016/j.cmet.2020.08.017. PMID: 32976758. PMCID: PMC7642105 (available on 2021-11-03) pdf.
2017
Rajan A#*, Housden BE, Wirtz-Peitz, Holderbaum L, Perrimon N#. (2017). A mechanism coupling systemic energy sensing to adipokine secretion. Developmental Cell, 43(1): 83-98. PMCID: PMC5650192. (#corresponding authors; *Lead author). download pdf.
Pre-Rajan Lab publications
2013
Rajan A# and Perrimon N#. (2013). Of flies and men: insights on organismal metabolism from fruit flies. BMC Biology, 11: 38. PMCID: 23587196. (#corresponding authors). download pdf.
2012
Rajan A# and Perrimon N#. (2012). The Drosophila cytokine Unpaired2 regulates physiological homeostasis by remotely controlling Insulin secretion. Cell, 151: 123-137. PMCID: PMC3475207. (#corresponding authors). download pdf.
2011
Rajan A and Perrimon N. (2011). Drosophila as a model for interorgan communication: Lessons from studies on energy homeostasis. Developmental Cell, 21:29-31. PMID: 21763605. download pdf.
Tong C, Ohyama T, Tien AC, Rajan A, Haueter CM, Bellen HJ. (2011). Rich regulates target specificity of photoreceptor cells and N-Cadherin trafficking in the Drosophila visual system via Rab6. Neuron, 71: 447-459. PMCID: PMC3166630. download pdf.
2010
Rajan A and Perrimon N. (2010). Steroids make you bigger? Fat chance says dMyc. Cell Metabolism, 12:7-9. PMID: 20620990. download pdf.
2009
Rajan A*, Tien AC*, Haueter CM, Schulze KL, Bellen HJ. (2009). The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nature Cell Biology, 11:815-24. (*equal contribution). PMCID: PMC3132077. download pdf.
2008
Tien AC*, Rajan A*, Schulze KL, Ryoo HD, Acar M, Steller H, Bellen HJ. (2008). Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of Lin12-Notch repeats in Drosophila melanogaster. Journal of Cell Biology, 182: 1113-1125. (*equal contribution). PMCID: PMC2542473. download pdf.
2007
Acar M, Jafar-Nejad H, Takeuchi H, Rajan A, Ibrani D, Rana NA, Pan H, Haltiwanger RS, Bellen HJ. (2007). Rumi, a CAP10 domain protein, is a glycosyltransferase that modifies Notch and is required for Notch signaling. Cell, 132: 247-258. PMCID: PMC2275919. download pdf.
Ohyama T, Verstreken P, Ly CV, Rosenmund T, Rajan A, Tien AC, Haueter C, Schulze KL, Bellen HJ. (2007). Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles. Journal of Cell Biology, 179: 1481-1496. PMCID: PMC2373489. download pdf.